3m1s

Publication Abstract from PubMed

The 3.15-A-resolution crystal structure of the R enantiomer of the highly bioactive and antiproliferative half-sandwich ruthenium complex DW12 bound to the ATP binding site of glycogen synthase kinase 3beta (GSK-3beta) is reported and the binding is compared with the GSK-3beta binding of staurosporine and other organic inhibitors. The structure reveals a close packing of the organometallic inhibitor in the ATP binding site of GSK-3beta via an induced-fit mechanism. The molecular structure of (R)-DW12 with the CO ligand oriented perpendicular to the pyridocarbazole heterocycle allows the complex to stretch the whole distance sandwiched between the faces of the N- and C-terminal lobes and to interact tightly with the flexible glycine-rich loop, which is uncommon for the interaction of GSK-3beta with organic inhibitors.

Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta.,Atilla-Gokcumen GE, Di Costanzo L, Meggers E J Biol Inorg Chem. 2010 Sep 7. PMID:20821241^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.