Structural highlights
3mvg is a 2 chain structure with sequence from Iris x hollandica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 2b7u, 1bry, 1ahc, 1nio, 1rl0, 2oqa |
| Activity: | rRNA N-glycosylase, with EC number 3.2.2.22 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The most abundant protein of Iris bulbs has been identified as a type 1 ribosome-inactivating protein (RIP). Analysis of the purified proteins and molecular cloning of the corresponding cDNAs demonstrated that this type 1 RIP is a mixture of three isoforms that exhibit a high degree of sequence identity and have similar, though not identical, ribosome-inactivating and polynucleotide:adenosine glycosidase activities. The accumulation of large quantities of type 1 RIP in a vegetative storage organ suggests that this presumed defence-related protein also plays a role in the nitrogen-storage metabolism of the bulb.
Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning.,Van Damme EJ, Barre A, Barbieri L, Valbonesi P, Rouge P, Van Leuven F, Stirpe F, Peumans WJ Biochem J. 1997 Jun 15;324 ( Pt 3):963-70. PMID:9210423[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Van Damme EJ, Barre A, Barbieri L, Valbonesi P, Rouge P, Van Leuven F, Stirpe F, Peumans WJ. Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning. Biochem J. 1997 Jun 15;324 ( Pt 3):963-70. PMID:9210423
