1rec

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Image:1rec.gif


PDB ID 1rec

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, resolution 1.9Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION


Overview

Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs.

About this Structure

1REC is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recoverin, a calcium sensor in vision., Flaherty KM, Zozulya S, Stryer L, McKay DB, Cell. 1993 Nov 19;75(4):709-16. PMID:8242744

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