1rjb

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spinqualitylabelsall models PDB ID 1rjb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.10Å
Activity:	Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Coordinates:	save as pdb, mmCIF, xml

Crystal Structure of FLT3

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively activated forms of the receptor that are found in significant numbers of patients with acute myelogenous leukemia (AML). The mutations occur either in the activation loop, for example, as point mutations of Asp835 or as internal tandem duplication (ITD) sequences in the juxtamembrane (JM) domain. To further understand the nature of FLT3 autoinhibition and regulation, we have determined the crystal structure of the autoinhibited form of FLT3. This structure shows the autoinhibitory conformation of a complete JM domain in this class of receptor tyrosine kinases. The detailed inhibitory mechanism of the JM domain is revealed, which is likely utilized by other members of type III receptor tyrosine kinases.

Disease

Known diseases associated with this structure: Leukemia, acute lymphoblastic OMIM:[136351], Leukemia, acute myeloid OMIM:[136351], Leukemia, acute myeloid, reduced survival in OMIM:[136351], Melanoma, malignant sporadic OMIM:[602216], Pancreatic cancer, sporadic OMIM:[602216], Peutz-Jeghers syndrome OMIM:[602216], Testicular tumor, sporadic OMIM:[602216]

About this Structure

1RJB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain., Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K, Mol Cell. 2004 Jan 30;13(2):169-78. PMID:14759363

Page seeded by OCA on Thu Mar 20 13:52:20 2008