This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1s3a
From Proteopedia
| |||||||
| Gene: | NDUFA2 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)
Overview
Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.
About this Structure
1S3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The oxidized subunit B8 from human complex I adopts a thioredoxin fold., Brockmann C, Diehl A, Rehbein K, Strauss H, Schmieder P, Korn B, Kuhne R, Oschkinat H, Structure. 2004 Sep;12(9):1645-54. PMID:15341729
Page seeded by OCA on Thu Mar 20 13:59:53 2008
Categories: Homo sapiens | Single protein | Brockmann, C. | Diehl, A. | Kuhne, R. | Oschkinat, H. | Rehbein, K. | Ci-b8 | Complex i | Ndufa2 | Nmr
