This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2c26
From Proteopedia
|
STRUCTURAL BASIS FOR THE PROMISCUOUS SPECIFICITY OF THE CARBOHYDRATE-BINDING MODULES FROM THE BETA-SANDWICH SUPER FAMILY
Overview
Enzyme systems that attack the plant cell wall contain noncatalytic, carbohydrate-binding modules (CBMs) that mediate attachment to this, composite structure and play a pivotal role in maximizing the hydrolytic, process. Although xyloglucan, which includes a backbone of beta-1,4-glucan, decorated primarily with xylose residues, is a key component of the plant, cell wall, CBMs that bind to this polymer have not been identified. Here, we showed that the C-terminal domain of the modular Clostridium, thermocellum enzyme CtCel9D-Cel44A (formerly known as CelJ) comprises a, novel CBM (designated CBM44) that binds with equal affinity to cellulose, and xyloglucan. We also showed that accommodation of xyloglucan side, chains is a general feature of CBMs that bind to single cellulose chains., The ... [(full description)]
About this Structure
2C26 is a [Single protein] structure of sequence from [Clostridium thermocellum] with CA and EDO as [ligands]. Full crystallographic information is available from [OCA].
Reference
Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains., Najmudin S, Guerreiro CI, Carvalho AL, Prates JA, Correia MA, Alves VD, Ferreira LM, Romao MJ, Gilbert HJ, Bolam DN, Fontes CM, J Biol Chem. 2006 Mar 31;281(13):8815-28. Epub 2005 Nov 28. PMID:16314409
Page seeded by OCA on Mon Oct 29 16:51:14 2007
Categories: Clostridium thermocellum | Single protein | Alves, V.D. | Bolam, D.N. | Carvalho, A.L. | Correia, M.A.S. | Ferreira, L.M.A. | Fontes, C.M.G.A. | Gilbert, H.J. | Guerreiro, C.I.P.D. | Najmudin, S. | Prates, J.A.M. | Romao, M.J. | CA | EDO | Beta-sandwich proteins | Carbohydrate binding module | Cbm44 | Cellulase ctcel9d-cel44a | Cellulosome | Hydrolase | Pkd domain
