1svc

From Proteopedia

Revision as of 12:10, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1svc.gif


PDB ID 1svc

Drag the structure with the mouse to rotate
, resolution 2.600Å
Coordinates: save as pdb, mmCIF, xml



NFKB P50 HOMODIMER BOUND TO DNA


Overview

The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53.

About this Structure

1SVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the NF-kappa B p50 homodimer bound to DNA., Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC, Nature. 1995 Jan 26;373(6512):311-7. PMID:7830764

Page seeded by OCA on Thu Mar 20 14:10:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1svc"
Personal tools