Structural highlights
4n61 is a 4 chain structure with sequence from Influenza a virus (a/shanghai/02/2013(h7n9)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 4n5j, 4n5k, 4n60, 4n62, 4n63, 4n64 |
| Gene: | HA, hemagglutinin (Influenza A virus (A/Shanghai/02/2013(H7N9))) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The 2013 outbreak of avian-origin H7N9 influenza in eastern China has raised concerns about its ability to transmit in the human population. The hemagglutinin glycoprotein of most human H7N9 viruses carries Leu(226), a residue linked to adaptation of H2N2 and H3N2 pandemic viruses to human receptors. However, glycan array analysis of the H7 hemagglutinin reveals negligible binding to humanlike alpha2-6-linked receptors and strong preference for a subset of avian-like alpha2-3-linked glycans recognized by all avian H7 viruses. Crystal structures of H7N9 hemagglutinin and six hemagglutinin-glycan complexes have elucidated the structural basis for preferential recognition of avian-like receptors. These findings suggest that the current human H7N9 viruses are poorly adapted for efficient human-to-human transmission.
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses.,Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, Yu W, Paulson JC, Wilson IA Science. 2013 Dec 6;342(6163):1230-5. doi: 10.1126/science.1243761. PMID:24311689[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, Yu W, Paulson JC, Wilson IA. Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science. 2013 Dec 6;342(6163):1230-5. doi: 10.1126/science.1243761. PMID:24311689 doi:http://dx.doi.org/10.1126/science.1243761
