Structural highlights
Publication Abstract from PubMed
The crystallographic structure of the synthetic oligoribonucleotide, U(UA)6A, has been solved at 2.25 A resolution. The crystallographic refinement permitted the identification of 91 solvent molecules, with a final agreement factor of 13%. The molecule is a dimer of 14 base-pairs and shows the typical features of an A-type helix. However, the presence of two kinks causes a divergence from a straight helix. The observed deformation, which is stabilized by a few hydrogen bonds in the crystal packing, could be due to the relatively high (35 degrees C) temperature of crystallization. The complete analysis of the structure is presented. It includes the stacking geometries, the backbone conformation and the solvation.
Crystallographic structure of an RNA helix: [U(UA)6A]2.,Dock-Bregeon AC, Chevrier B, Podjarny A, Johnson J, de Bear JS, Gough GR, Gilham PT, Moras D J Mol Biol. 1989 Oct 5;209(3):459-74. PMID:2479753[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Dock-Bregeon AC, Chevrier B, Podjarny A, Johnson J, de Bear JS, Gough GR, Gilham PT, Moras D. Crystallographic structure of an RNA helix: [U(UA)6A]2. J Mol Biol. 1989 Oct 5;209(3):459-74. PMID:2479753
