| Structural highlights
2qlt is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , , , |
| Gene: | GPP1, RHR2, YIL053W (Saccharomyces cerevisiae) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum, TOPSAN |
Function
[GPP1_YEAST] Major isoform of glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation and required for adaptation to anaerobic conditions.[1] [2] [3] [4] [5]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L. Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1996 Jun 7;271(23):13875-81. PMID:8662716
- ↑ Pahlman AK, Granath K, Ansell R, Hohmann S, Adler L. The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. J Biol Chem. 2001 Feb 2;276(5):3555-63. Epub 2000 Oct 31. PMID:11058591 doi:http://dx.doi.org/10.1074/jbc.M007164200
- ↑ Nguyen HT, Dieterich A, Athenstaedt K, Truong NH, Stahl U, Nevoigt E. Engineering of Saccharomyces cerevisiae for the production of L-glycerol 3-phosphate. Metab Eng. 2004 Apr;6(2):155-63. PMID:15113568 doi:http://dx.doi.org/10.1016/j.ymben.2004.02.005
- ↑ Granath K, Modig T, Forsmark A, Adler L, Liden G. The YIG1 (YPL201c) encoded protein is involved in regulating anaerobic glycerol metabolism in Saccharomyces cerevisiae. Yeast. 2005 Dec;22(16):1257-68. PMID:16358322 doi:http://dx.doi.org/10.1002/yea.1307
- ↑ Popp A, Nguyen HT, Boulahya K, Bideaux C, Alfenore S, Guillouet SE, Nevoigt E. Fermentative production of L-glycerol 3-phosphate utilizing a Saccharomyces cerevisiae strain with an engineered glycerol biosynthetic pathway. Biotechnol Bioeng. 2008 Jun 15;100(3):497-505. doi: 10.1002/bit.21777. PMID:18438874 doi:http://dx.doi.org/10.1002/bit.21777
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