Structural highlights
Function
[NKX31_HUMAN] Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.[1]
References
- ↑ Zhang P, Liu W, Zhang J, Guan H, Chen W, Cui X, Liu Q, Jiang A. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. Mol Biol Rep. 2010 Mar;37(3):1505-12. doi: 10.1007/s11033-009-9549-8. Epub 2009, May 22. PMID:19462257 doi:http://dx.doi.org/10.1007/s11033-009-9549-8
