1xud

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Image:1xud.jpg


PDB ID 1xud

Drag the structure with the mouse to rotate
, resolution 1.800Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor


Overview

The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.

About this Structure

1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640

Page seeded by OCA on Thu Mar 20 15:14:38 2008

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