| Structural highlights
4gos is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , |
| Gene: | B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 (Homo sapiens) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[VTCN1_HUMAN] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.[1] [2] [3] [4] [UniProtKB:Q7TSP5]
References
- ↑ Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp Cell Res. 2005 May 15;306(1):128-41. PMID:15878339 doi:http://dx.doi.org/10.1016/j.yexcr.2005.01.018
- ↑ Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med. 2006 Apr 17;203(4):871-81. Epub 2006 Apr 10. PMID:16606666 doi:http://dx.doi.org/10.1084/jem.20050930
- ↑ Kryczek I, Wei S, Zhu G, Myers L, Mottram P, Cheng P, Chen L, Coukos G, Zou W. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 2007 Sep 15;67(18):8900-5. PMID:17875732 doi:http://dx.doi.org/10.1158/0008-5472.CAN-07-1866
- ↑ Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol Oncol. 2007 Jul;106(1):119-27. Epub 2007 May 16. PMID:17509674 doi:http://dx.doi.org/S0090-8258(07)00198-9
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