1hu9
From Proteopedia
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 4-HYDROPEROXY-2-METHOXY-PHENOL
Overview
Scientific research provides documented evidence that fatty acid, metabolites have profound impact on carcinogenesis. Intervention into, dioxygenase pathways might therefore effect development, metastasis and, progression of many types of cancers. This work delivers the first 3D, structural data and explains how curcumin interacts with the fatty acid, metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase, in a non-competitive manner. Trapped in that complex, it undergoes, photodegradation in the X-rays, but utilizes enzyme catalytic ability to, form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our, observations about this radiation and time-dependent inhibition add new, information ... [(full description)]
About this Structure
1HU9 is a [Single protein] structure of sequence from [Glycine max] with FE and 4HM as [ligands]. Active as [[1]], with EC number [1.13.11.12]. Full crystallographic information is available from [OCA].
Reference
Structure of curcumin in complex with lipoxygenase and its significance in cancer., Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J, Int J Mol Med. 2003 Jul;12(1):17-24. PMID:12792803
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