1z4u
From Proteopedia
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , and | ||||||
| Activity: | RNA-directed RNA polymerase, with EC number 2.7.7.48 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585
Overview
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
About this Structure
1Z4U is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260
Page seeded by OCA on Thu Mar 20 15:31:12 2008
Categories: Hepatitis c virus | Protein complex | RNA-directed RNA polymerase | Anstadt, R. | Finzel, B C. | Greene, M. | Gross, R J. | Harris, M S. | Mitchell, M A. | Nugent, R. | Pfefferkorn, J A. | Shelly, J A. | Wells, P A. | CL | GOL | PH9 | PO4 | Finger | Hcv | Ns5b | Palm | Polymerase | Thumb
