2ak4

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spinqualitylabelsall models PDB ID 2ak4 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.500Å
Ligands:
Coordinates:	save as pdb, mmCIF, xml

Crystal Structure of SB27 TCR in complex with HLA-B*3508-13mer peptide

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contacts were made with MHC class I. Although the TCR-peptide recognition resembled an antibody-antigen interaction, the TCR-MHC class I contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2AK4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide., Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, Beddoe T, Whisstock JC, Wilce MC, Silins SL, Burrows JM, Kjer-Nielsen L, Kostenko L, Purcell AW, McCluskey J, Rossjohn J, Nat Immunol. 2005 Nov;6(11):1114-22. Epub 2005 Sep 25. PMID:16186824

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