Structural highlights
Function
[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]
References
- ↑ Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200
