2b53

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Image:2b53.gif


PDB ID 2b53

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, resolution 2.00Å
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Coordinates: save as pdb, mmCIF, xml



Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325


Overview

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.

About this Structure

2B53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Quinazolines as cyclin dependent kinase inhibitors., Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60. PMID:11354366

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