2bz6

From Proteopedia

Revision as of 14:08, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2bz6.gif


PDB ID 2bz6

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites:
Ligands: , and
Activity: Coagulation factor VIIa, with EC number 3.4.21.21
Coordinates: save as pdb, mmCIF, xml



ORALLY AVAILABLE FACTOR7A INHIBITOR


Contents

Overview

The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial thrombosis without prolonging bleeding time. The pharmacodynamic properties of this selective inhibitor are compared to the behaviour of a mixed factor VIIa/factor Xa inhibitor.

Disease

Known diseases associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2BZ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity., Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lave T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U, Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. Epub 2006 Apr 18. PMID:16621574

Page seeded by OCA on Thu Mar 20 16:08:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bz6"
Personal tools