3so5

Structural highlights

Function

[LRIG3_MOUSE] Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.^{[1] [2]}

References

1. ↑ Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9. doi: 10.1242/dev.029330. Epub 2008 Nov 12. PMID:19004851 doi:10.1242/dev.029330
2. ↑ Abraira VE, Satoh T, Fekete DM, Goodrich LV. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. PLoS One. 2010 Feb 1;5(2):e8981. doi: 10.1371/journal.pone.0008981. PMID:20126551 doi:10.1371/journal.pone.0008981