2cua
From Proteopedia
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| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | Cytochrome-c oxidase, with EC number 1.9.3.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CUA DOMAIN OF CYTOCHROME BA3 FROM THERMUS THERMOPHILUS
Overview
The structure of the CuA-containing, extracellular domain of Thermus thermophilus ba3-type cytochrome c oxidase has been determined to 1.6 A resolution using multiple X-ray wavelength anomalous dispersion (MAD). The Cu2S2 cluster forms a planar rhombus with a copper-copper distance of 2.51 +/- 0.03 A. X-ray absorption fine-structure (EXAFS) studies show that this distance is unchanged by crystallization. The CuA center is asymmetrical; one copper is tetrahedrally coordinated to two bridging cysteine thiolates, one histidine nitrogen and one methionine sulfur, while the other is trigonally coordinated by the two cysteine thiolates and a histidine nitrogen. Combined sequence-structure alignment of amino acid sequences reveals conserved interactions between cytochrome c oxidase subunits I and II.
About this Structure
2CUA is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6 A resolution., Williams PA, Blackburn NJ, Sanders D, Bellamy H, Stura EA, Fee JA, McRee DE, Nat Struct Biol. 1999 Jun;6(6):509-16. PMID:10360350
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