Structural highlights
4fts is a 4 chain structure with sequence from Flock house virus and Spodoptera frugiperda. This structure supersedes the now removed PDB entry 2q23. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 3lob, 1nov, 2bbv, 1f8v, 4fsj, 4ftb, 4fte |
| Gene: | alpha, coat protein alpha (Flock house virus) |
| Activity: | Nodavirus endopeptidase, with EC number 3.4.23.44 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[CAPSD_FHV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).
See Also
