4gcn

Structural highlights

Function

[O16259_CAEEL] Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity.^{[1] [2]}

References

1. ↑ Song HO, Lee W, An K, Lee HS, Cho JH, Park ZY, Ahnn J. C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. J Mol Biol. 2009 Jul 24;390(4):604-17. doi: 10.1016/j.jmb.2009.05.035. Epub 2009 , May 23. PMID:19467242 doi:http://dx.doi.org/10.1016/j.jmb.2009.05.035
2. ↑ Gaiser AM, Brandt F, Richter K. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. J Mol Biol. 2009 Aug 21;391(3):621-34. Epub 2009 Jun 25. PMID:19559711 doi:http://dx.doi.org/S0022-2836(09)00769-4