2dn6

Structural highlights

Function

[SWP70_HUMAN] Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D. Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2180-4. PMID:10681448 doi:http://dx.doi.org/10.1073/pnas.040374497
2. ↑ Hilpela P, Oberbanscheidt P, Hahne P, Hund M, Kalhammer G, Small JV, Bahler M. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell. 2003 Aug;14(8):3242-53. Epub 2003 Apr 17. PMID:12925760 doi:http://dx.doi.org/10.1091/mbc.E03-01-0043