1v6e

Structural highlights

Function

[TBCB_MOUSE] Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kortazar D, Fanarraga ML, Carranza G, Bellido J, Villegas JC, Avila J, Zabala JC. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Exp Cell Res. 2007 Feb 1;313(3):425-36. Epub 2006 Sep 9. PMID:17184771 doi:http://dx.doi.org/10.1016/j.yexcr.2006.09.002
2. ↑ Lopez-Fanarraga M, Carranza G, Bellido J, Kortazar D, Villegas JC, Zabala JC. Tubulin cofactor B plays a role in the neuronal growth cone. J Neurochem. 2007 Mar;100(6):1680-7. Epub 2007 Jan 8. PMID:17217416 doi:http://dx.doi.org/10.1111/j.1471-4159.2006.04328.x