Sandbox Reserved 962

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Revision as of 15:25, 29 December 2014 by Laure Hertzog (Talk | contribs)
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This Sandbox is Reserved from 15/11/2014, through 15/05/2015 for use in the course "Biomolecule" taught by Bruno Kieffer at the Strasbourg University. This reservation includes Sandbox Reserved 951 through Sandbox Reserved 975.
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mRNA Cap (Guanine-N7) Methyltransferase (Ecm1)


Ecm1

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Contents

Function

Structure

Interaction

Cap Analog Binding (7-methylguanosine-5-triphosphate-5-Guanosine)

binds to the enzyme in a pocket near the AdoHcy. are involded in the binding of the cap analog. The cap makes Van der Walls contacts, hydrogen bond and water mediated bond.


AdoHcy Binding (S-adenosyl-L-homocysteine)

The mRNA Cap Methyltransferase bind to which is the product of the methyl donor AdoMet after the methylation. AdoHcys is in a pocket formed by amino acids of segment 2. (Lys54, Gly72, Asp78, Asp94, Ile95, Asp122, Ser124, Gln140, Phe141, Ser142) are involved in the stabilisation of AdoHcys. The interactions between AdoHcys and the enzyme are made of : hydrogen bonds, Van der Walls interactions,electrostatic interaction and water mediated contact. [1]

Post transcriptional modifications

References

  1. ↑ Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD. Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396
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