2j6j
From Proteopedia
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PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN
Overview
Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion, via a low pH-induced structural rearrangement. Despite the equilibrium, between the pre- and postfusion states, the structure of the prefusion, form, determined to 3.0 angstrom resolution, shows that the fusogenic, transition entails an extensive structural reorganization of G. Comparison, with the structure of the postfusion form suggests a pathway for the, conformational change. In the prefusion form, G has the shape of a tripod, with the fusion loops exposed, which point toward the viral membrane, and, with the antigenic sites located at the distal end of the molecule. A, large number of G glycoproteins, perhaps organized as in the crystals, act, cooperatively to induce membrane merging.
About this Structure
2J6J is a [Single protein] structure of sequence from [Vesicular stomatitis indiana virus] with NAG and YB as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G., Roche S, Rey FA, Gaudin Y, Bressanelli S, Science. 2007 Feb 9;315(5813):843-8. PMID:17289996
Page seeded by OCA on Mon Oct 29 16:57:58 2007
