Structural highlights
Publication Abstract from PubMed
Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA.
Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.,Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T. Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained. Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102 doi:10.1002/chem.201102979
