Structural highlights
Publication Abstract from PubMed
Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.
A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides.,Kondo J Angew Chem Int Ed Engl. 2011 Nov 23. doi: 10.1002/anie.201106084. PMID:22110016[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kondo J. A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides. Angew Chem Int Ed Engl. 2011 Nov 23. doi: 10.1002/anie.201106084. PMID:22110016 doi:10.1002/anie.201106084
