2j6k
From Proteopedia
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N-TERMINAL SH3 DOMAIN OF CMS (CD2AP HUMAN HOMOLOG)
Overview
The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic, adaptor proteins has the ability to engage multiple effectors and couple, cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with, multiple Src homology 3 (SH3) domains) facilitate the formation of large, multiprotein complexes required for an efficient internalization of cell, surface receptors. It has recently been shown that c-Cbl/Cbl-b could, mediate the formation of a ternary complex between one c-Cbl/Cbl-b, molecule and two SH3 domains of CIN85, important for the ability of Cbl to, promote epidermal growth factor receptor down-regulation. To further, investigate whether multimerization is conserved within the family of, adaptor proteins, we have solved the crystal structures of the CMS, ... [(full description)]
About this Structure
2J6K is a [Single protein] structure of sequence from [Homo sapiens] with NA as [ligand]. Full crystallographic information is available from [OCA].
Reference
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880
Page seeded by OCA on Mon Oct 29 16:58:28 2007
Categories: Homo sapiens | Single protein | Bravo, J. | Cardenes, N. | Deribe, Y.L. | Dikic, I. | Moncalian, G. | Spinola-Amilibia, M. | NA | Adaptor protein | Cd2 associated protein | Coiled coil | Cytoskeletal rearrangements | Egfr downregulation | Phosphorylation | Protein binding | Sh3 | Sh3 domain | Sh3-binding | Signaling protein | Surface active protein
