2hmh

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spinqualitylabelsall models PDB ID 2hmh Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.00Å
Gene:	Socs3 (Mus musculus)
Coordinates:	save as pdb, mmCIF, xml

Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.

Overview

Suppressor of cytokine signaling (SOCS) proteins are indispensable negative regulators of cytokine-stimulated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathways. SOCS proteins (SOCS1-7 and CIS) consist of a variable N-terminal region, a central Src homology-2 (SH2) domain, and a C-terminal SOCS box. The N-terminal region in SOCS1 and SOCS3 includes the so-called kinase inhibitory region that has been shown to inhibit the catalytic activity of JAK2. Here, we present a crystal structure at 2.0 A resolution of the N-terminally extended SH2 domain of SOCS3 in complex with its phosphopeptide target on the cytokine receptor gp130. The structure reveals that major insertions in the EF and BG loops of the SOCS3 SH2 domain are responsible for binding to gp130 with high affinity and specificity. In addition, the structure provides insights into the possible mechanisms by which SOCS3 and SOCS1 inhibit JAK2 kinase activity.

About this Structure

2HMH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3., Bergamin E, Wu J, Hubbard SR, Structure. 2006 Aug;14(8):1285-92. PMID:16905102

Page seeded by OCA on Thu Mar 20 17:18:51 2008