2i47

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Image:2i47.gif


PDB ID 2i47

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, resolution 1.9Å
Ligands: , and
Activity: ADAM 17 endopeptidase, with EC number 3.4.24.86
Coordinates: save as pdb, mmCIF, xml



Crystal structure of catalytic domain of TACE with inhibitor


Overview

By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.

About this Structure

2I47 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification of potent and selective TACE inhibitors via the S1 pocket., Condon JS, Joseph-McCarthy D, Levin JI, Lombart HG, Lovering FE, Sun L, Wang W, Xu W, Zhang Y, Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. Epub 2006 Oct 5. PMID:17064892

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