Structural highlights
2arx is a 2 chain structure with sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , , |
| Related: | 2ar6, 2arb, 2are |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.
Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin.,Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R. Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin. FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415 doi:10.1111/j.1742-4658.2006.05248.x
