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2nxp

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Revision as of 15:52, 20 March 2008 by OCA (Talk | contribs)
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Image:2nxp.gif


PDB ID 2nxp

Drag the structure with the mouse to rotate
, resolution 2.17Å
Ligands:
Gene: TAF5 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structure of NTD2 domain of the human TAF5 subunit of TFIID


Overview

TFIID is an essential factor required for RNA polymerase II transcription but remains poorly understood because of its intrinsic complexity. Human TAF5, a 100-kDa subunit of general transcription factor TFIID, is an essential gene and plays a critical role in assembling the 1.2 MDa TFIID complex. We report here a structural analysis of the TAF5 protein. Our structure at 2.2-A resolution of the TAF5-NTD2 domain reveals an alpha-helical domain with distant structural similarity to RNA polymerase II CTD interacting factors. The TAF5-NTD2 domain contains several conserved clefts likely to be critical for TFIID complex assembly. Our biochemical analysis of the human TAF5 protein demonstrates the ability of the N-terminal half of the TAF5 gene to form a flexible, extended dimer, a key property required for the assembly of the TFIID complex.

About this Structure

2NXP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis and dimerization potential of the human TAF5 subunit of TFIID., Bhattacharya S, Takada S, Jacobson RH, Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1189-94. Epub 2007 Jan 16. PMID:17227857

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