Sandbox tech1

From Proteopedia

Revision as of 10:06, 10 February 2015 by Student (Talk | contribs)
Jump to: navigation, search

Lysozyme is a relatively small (129 AA) enzyme that catalyzes the hydrolysis of specific kinds of polysaccharides comprising the cell walls of bacteria.

In birds, lysozyme is an exceptionally abundant protein in fowl egg whites where it likely functions both as an antibiotic (see below) as well as a nutrient for early embryogenesis. In vertebrates, this "glycosidase" is found mainly in biological secretions (such as tears) where it probably serves as an anti-bacterial agent by digesting and weakening the rigid bacterial cell wall, thereby rendering the bacterial susceptible to osmotic lysis. The effect of lysozyme is similar to the effect of penicillin which also weakens the cell walls of bacteria only by irreversibly inhibiting a transpeptidase enzyme required for crosslinking peptidoglycan macromolecules formed in the biosynthesis of the cell wall. Under normal conditions, bacteria grow very rapidly in some cases doubling more than once in an hour. However, when cell wall crosslinking is disrupted, bacteria tend to lyse in hypotonic media as a result of the mechanical weakening of their cell walls [1]. This is a picture of is one of the key amino acid residue responsible for fluorescence property of HEWL.


References 1. http://mcdb-webarchive.mcdb.ucsb.edu/sears/biochemistry/tw-enz/lysozyme/HEWL/lysozyme-overview.htm ==

Contents

Headline text 

==

of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Function

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_tech1"
Personal tools