4x4w

Structural highlights

Function

[TRNT1_HUMAN] Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.^[1] Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).^[2]

References

1. ↑ Lizano E, Schuster J, Muller M, Kelso J, Morl M. A splice variant of the human CCA-adding enzyme with modified activity. J Mol Biol. 2007 Mar 2;366(4):1258-65. Epub 2006 Dec 12. PMID:17204286 doi:http://dx.doi.org/10.1016/j.jmb.2006.12.016
2. ↑ Lizano E, Schuster J, Muller M, Kelso J, Morl M. A splice variant of the human CCA-adding enzyme with modified activity. J Mol Biol. 2007 Mar 2;366(4):1258-65. Epub 2006 Dec 12. PMID:17204286 doi:http://dx.doi.org/10.1016/j.jmb.2006.12.016