Sandbox 820

Function

UBA1's place in the Ubiquitination process, E1 what that means etc.

Structural highlights

overall structure, bound structure, monomer, active site catalytic residues. The of Uba1 consists of six structural domains (IAD, AAD, FCCH, SCCH, 4HB, and UFD), four of which pack together to create a central canyon.{Lee, 2008} The canyon is divided into two distinct clefts (left and right) by the SCCH/AAD linker fragment.{Lee, 2008} Ubiquitin binds to the cysteine located on the right cleft of Uba1 which allows for Ubiquitin to orient itself relative to the active site located on the left cleft.{Lee, 2008} The structure of results in a change in conformation that buries a significant portion of Uba1 exposed surface area.{Lee, 2008}

References