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2qcx

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Revision as of 16:24, 20 March 2008 by OCA (Talk | contribs)
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Image:2qcx.jpg


PDB ID 2qcx

Drag the structure with the mouse to rotate
, resolution 2.200Å
Sites: and
Ligands:
Gene: tenA (Bacillus subtilis)
Activity: Thiaminase, with EC number 3.5.99.2
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Bacillus subtilis TenA Y112F mutant complexed with formyl aminomethyl pyrimidine


Overview

TenA catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine and participates in the salvage of base-degraded thiamin. Here, we describe mutagenesis of the active site of TenA guided by structures of the enzyme complexed to a substrate analog and to the product. Catalytic roles for each of the active site residues are identified and a mechanism for the reaction is described.

About this Structure

2QCX is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis., Jenkins AL, Zhang Y, Ealick SE, Begley TP, Bioorg Chem. 2008 Feb;36(1):29-32. Epub 2007 Dec 3. PMID:18054064

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