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Introduction

Headline text

This is a sample scene created with SAT to by Group, and another to make of the protein.

Introduction guide line: Glycogen Synthase Kinase-3 (GSK-3)

1. Begin with "GSK-3 is serine/threonine protein kinase..." explain what that is (structure and general function)

2. Speak about GSK-3 alpha and GSK-3 beta. 3. Begin to describe green screen in relation to the general structure of serine/threonine protein kinase --> specific differences in GSK-3 4. Talk about which species contain GSK-3 5. Speak about where in which species bodies GSK-3 is present versus humans 6. Explain function in different species structures versus humans

  Talk about interactions with other molecules and effects of these interactions. 

7. Effects of changing concentrations of GSK-3 and effects of changing the concentrations of molecules it interacts with

  Talk about potential effects of mutations 

8. Lead previous section (effects of varying amounts and interactions) into diseases caused by GSK-3. Talk about potential therapeutic uses of it and new treatments under research.

Green Screen Caption: Show GSK-3 alpha and GSK-3 beta (if possible?)

Overall Structure

-Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine protein kinase -2 isoforms: alpha and beta, that are 97% homologous in their catalytic domain, but diverse at the N and C terminus. -Both isoforms have a conserved N-terminal serine reside (S21 for alpha and S9 for beta) -Phosphorylation of the N-terminal serine residue plays an important role for further activity -Classified the PDB structures into three groups a

Mishra, Nibha et al. Structure based virtual screening of GSK-3beta: Importance of protein flexibility and induced fit, 2009. Bioorganic & Medicinal Chemistry Letters, 2009, Vol. 19 Iss. 19, pp. 5582-5585. Retreived from http://www.sciencedirect.com/science/article/pii/S0960894X09011780

Binding Interactions

Additional Features

Quiz Question 1

Test

Quiz Question 2

See Also

• UvrABC
• Glycogen Synthase Kinase 3
• Serine/Threonie Protein Kinase
• Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d
• Glycogen Synthase Kinase 3 Beta complexed with AMP-PNP
• Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4
• Glycogen Synthase Kinase 3 beta (GSK3B) complexed with a ruthenium octasporine ligand (OS1)

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - Nerses Haroutunian

Quiz Question 2 - name of team member

References