Sandbox Reserved 431
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| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
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***We may want to consider changing our pdb code to 4c9x rather than 4c9w. The only difference between them is which enantiomer of crizotinib MTH1 is binding to. 4c9w = R and 4c9x = S. The S enantiomer is the one that causes inhibition. --Matt
OurMolecule
Introduction
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This is a sample scene created with SAT to by Group, and another to make of the protein.
MTH1, also known as 7,8-dihydro-8-oxoguanine triphosphatase is an enzyme in the human body encodet by the NUDT1 gene.
MTH1 is an enzyme also know as 7,8-dihydro-8-oxoguanine triphosphatase that in the human organism is encoded by the NUDT1 gene. It is inhibited by (S)-Crizotinib which induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models.
Binding Interactions
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