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Introduction

This scene is of the within the Kappa Opioid Receptor by Group 3.

-"Kappa-Opioid receptors mediate the regulation of pain, respiratory drive, mood"
-"structure reveals important features of the ligand-binding pocket that contribute to the high affinity and subtype selectivity of JDTic for the human kappa-OR"
-consequences of stress as well as depression/anxiety
-hallucinogenic effects
-talk about mu and kappa OR
-intro to kappa-OR subtype selectivity

Overall Structure

Binding Interactions

Active Site of kappa Opioid Receptors

Common Ligands of Opioid Receptors

 Agonists - Mechanisms, Structure, and Effects
    Salvinorin A
    Morphine

 Antagonists - Mechanisms, Structure, and Effects
    JDTic
    Naloxone

Additional Features

Quiz Question 1

(include some basic structure of full protein in jmol window) - Where are the binding sites of the opioid receptor, and what conformational changes does the protein undergo while binding to ligands? What kinds of functional groups would the opioids have that bind to these sites?

Quiz Question 2

See Also

• UvrABC
• Opioid Receptor
• Mu Opioid Receptor Bound to a Morphinan Antagonist
• G protein-coupled Receptor

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - Leah Caffrey

Quiz Question 2 - name of team member

References