Introduction
This scene is of the within the Kappa Opioid Receptor by Group 3.
-"Kappa-Opioid receptors mediate the regulation of pain, respiratory drive, mood"
-"structure reveals important features of the ligand-binding pocket that contribute to the high affinity and subtype selectivity of JDTic for the human kappa-OR"
-consequences of stress as well as depression/anxiety
-hallucinogenic effects
-talk about mu and kappa OR
-intro to kappa-OR subtype selectivity
Overall Structure
Binding Interactions
Active Site of kappa Opioid Receptors
Common Ligands of Opioid Receptors
Agonists - Mechanisms, Structure, and Effects
Salvinorin A
Morphine
Antagonists - Mechanisms, Structure, and Effects
JDTic
Naloxone
Additional Features
Quiz Question 1
-include some basic structure of full protein in jmol window, maybe show charge distribution
- Where are the binding sites of the opioid receptor, and what conformational changes does the protein undergo while binding to ligands? What kinds of functional groups would opioids have that interact with these sites, enabling binding?
Quiz Question 2
See Also
Credits
Introduction - Patrick Harney
Overall Structure - Matthew Long
Drug Binding Site - Brandon Kittredge
Additional Features - Jacob Kellet
Quiz Question 1 - Leah Caffrey
Quiz Question 2 -
References
