Elongation factors (EF) facilitate translational elongation during the formation of peptide bonds in the ribosome.
- EF-selB is selenocysteine-specific EF.
- EF-Tu or EF 1-α (elongation factor thermo unstable) is a prokaryotic EF. EF-Tu contributes to translational accuracy. It catalyzes the addition of aminoacyl tRNA.
- EF-Ts or EF 1-β (elongation factor thermo stable) catalyzes the release of GDP from EF-Tu.
- EF-G translocates the peptidyl tRNA from the A site to the P site while moving the mRNA through the ribosome.
- EF-SII helps RNA polymerase II to bypass blocks to elongation.
- EF-ELL2 enhances polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex.
- EF-GreA or GreB are cleavage factors allowing the resumption of elongation.
- EF-NusA recruits translesion DNA polymerases to gaps encountered during translation.
- EF-P alters the ribosome affinity to aminoacyl-tRNA.
- EF-1 γ acts during the delivery of aminoacyl tRNA to the ribosome.
- EF-2 promotes the translocation of the nascent protein chain from the A site to the P site on the ribosome.
- EF-3 is a unique EF in fungi hence it provides an anti-fungal drug target.
- EF Spt4, Spt5, Spt6 are conserved among eukaryotes. They modulate the chromatin structure.
- EF-CA150 is believed to play a role in coupling transcription and splicing.
- Elongin B and C complex is involved in the proteasomal degredation of target proteins.
For EF-3 see HEAT Repeat
For EF-SelB see SelB.
