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Ephrin receptor

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Image:3hei.png

Crystal Structure of ephrin A2 receptor complex with ephrin, 3hei

Template:STRUCTURE 3fxx

Ephrin receptors (EPHR) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972). For more details see Ephrin Type-A Receptor.