Introduction
Tuberculosis, caused by Mycobacterium tuberculosis, is a respiratory infection still prevalent throughout the world. During the last decade, the emergence of multi-drug resistant strains of M. tuberculosis has given rise to the need for the development of new antibiotics in order to combat the infection. In order to develop an efficacious antibiotic, the drug must be able to target a unique aspect of the bacteria, such as a protein, that is critical for its full virulence and survival. MgtC, an integral protein embedded in the extracellular membrane of M. tuberculosis, has recently been hypothesized as a novel drug target to resolve tuberculosis infections. The targeting of MgtC was a result of observing that upon deletion of the protein from M. tuberculosis, the bacteria are no longer able to survive.
Function
Based on its tertiary structure, this protein has been placed into a larger group of proteins known as the MgtC superfamily. The overall structure of MgtC is constituted by two domains: an N-terminal domain and a C-terminal domain. Each of these domains have striking similarities and differences with other MgtC-like proteins.
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Disease
Relevance
Structural highlights
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