4yli

Structural highlights

Disease

[COL11_HUMAN] Craniofacial-ulnar-renal syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[COL11_HUMAN] Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).