General mechanism for the activation of fatty acids
FadD13 first activates the fatty acid through a reaction with ATP to form an acyl adenylate intermediate and release pyrophosphate. Following a conformational change of the enzyme, coenzyme A is able to bind and reaction with the acyl adenylate intermediate forming the acyl CoA product (Figure 1).
active site (to be copied over)
A high conserved residue in the C-terminal region,, resulted in a 95% loss of function of FadD13 and is thought to be involved in the orientation of the substrates to form the adenylate intermediate.[1] Other mutation studies, found that Serine 404 was involved in the binding of Coenzyme A which may only occur once the region incurs a 140 degree rotational change.[2][1]
Function
This is the .[3]
This is the .[3]
FadD13 has three different : The N-terminal region (1-395) is in blue, the C-terminal region (402-403) is in red, and the six amino acid linker is in tan (citation for original paper).
The adenine of ATP is bound to a group of that is structurally identically to other acyl-CoA synthetases (Citation for original paper).
citation 1 [2]
[3]
citation 2 [4]
[4]
Citation 3 [5]
[5]
Disease
Relevance
Structural highlights
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