Sandbox Reserved 1074

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This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
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Contents

Enoyl-ACP Reductase InhA from Mycobacterium tuberculosis

Enoyl-ACP Reductase InhA Homotetramer (PDB: 4OHU)

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References

  1. 1.0 1.1 1.2 1.3 Bell, A.F. et al.(2007). Evidence from Raman Spectroscopy That InhA , the Mycobacterial Enoyl Reductase, Modulates the Conformation of the NADH Cofactor to Promote Catalysis. Journal of the American Chemical Society, 129, 6425-6431. DOI: 10.1021/ja068219m
  2. 2.0 2.1 Bhatt, A. et al. (2007). The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Journal of Molecular Microbiology, 64(6), 1442-1454. PMID: 17555433 DOI: 10.1111/j.1365-2958.2007.05761.x
  3. Marrakchi, Hedia, et al. (2000). InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II. Journal of Microbiology, 146, 289-296. PMID: 10708367
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 Rozwarski, D.A. et al. (1999). Crystal Structure of the Mycobacterium tuberculosis Enoyl-ACP Reductase, InhA, in Complex with NAD+ and a C16 Fatty Acyl Substrate. Journal of Biological Chemistry, 274(22), 15582-15589. PMID: 10336454 DOI: 10.1074/jbc.274.22.15582
  5. 5.0 5.1 5.2 Vilchèze, C. et al. (2011). Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions. Antimicrobial Agents and Chemotherapy, 55(8), 3889-3898. DOI: 10.1128/AAC.00266-11


External Resources

Similar Proteopedia Pages

Additional 3D Structures of Enoyl-ACP Reductase InhA

4OXK, 4OXN, 4OXY, 4OYR, 4OIM, 4COD, 4DQU, 4DRE, 4DTI, 3FNE, 3FNF, 3FNG, 2IDZ, 2IE0, 2IEB, 2IED, 2H9I, 2NTJ, 2NV6, 2AQ8, 2AQH, 2AQI, 2AQK, 2B35, 2B36, 2B37, 1P44, 1P45, 1BVR, 1ZID, 1ENY, 1ENZ



Student Contributors

  • Arielle Russell
  • Mackenzie Smith
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