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2v5z

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Revision as of 16:43, 20 March 2008 by OCA (Talk | contribs)
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Image:2v5z.gif


PDB ID 2v5z

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites: , , and
Ligands: and
Activity: Amine oxidase (flavin-containing), with EC number 1.4.3.4
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE


Overview

Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.

About this Structure

2V5Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:17915852

Page seeded by OCA on Thu Mar 20 18:43:23 2008

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