Myeloperoxidase
From Proteopedia
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| Dog glycosylated myeloperoxidase dimer: heavy chain (pink and yellow), light chain (grey and green) containing heme complex with Ca+2 ions (green), 1d5l | |||||||||
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| Ligands: | , , | ||||||||
| Activity: | Peroxidase, with EC number 1.11.1.7 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Myeloperoxidase (MPO) catalyzes the production of HOCl from hydrogen peroxide and chloride ion during the neutrophil respiratory burst. The hypochlorous acid is used by the neutrophil to kill bacteria and other pathogens. MPO is a dimer consisting of 2 light chains and two variable-length heavy chains. MPO has a heme pigment which causes its green color in secretions like mucus which are rich in neutrophils.
3D structures of myeloperoxidase
Updated on 06-May-2015
1myp – MPO – dog
1mhl, 1cxp – hMPO C – human
3f9p - hMPO
1qo4 - MPO – Arabidopsis thaliana
1d2v – hMPO C + Br
1d5l – hMPO + CN
1d7w - hMPO + CN + Br
1dnu - hMPO + SCN
1dnw - hMPO + CN + SCN
3zs0, 3zs1, 4c1m - hMPO + inhibitor
4dl1 - hMPO + thioxanthine
4ejx - hMPO + ceruplasmin
